Unlocking the Mysteries of Diastolic Function

Unlocking the Mysteries of the Bounding Box

Few geospatial data representations are more basic than the bounding box; a rectangle surrounding a geographic feature or dataset. Bounding boxes are a key component of geospatial metadata and lie at the heart of many computational geometry algorithms as well as spatial indexing systems. Despite their ubiquity and common use, bounding boxes are more complicated than they first appear. The phras...

Unlocking the mysteries of TDP-43.

Cracking the mysteries of diastolic function in atrial fibrillation: new technology for an old problem.

Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia with an estimated number of 2.3 million U.S. citizens affected (1). Additionally, this number will only continue to increase because of an aging U.S. population—it is estimated that the number of affected individuals will double by 2050 (1). AF is often interlinked with some cardiac dysfunction. However, asses...

Integrative research: the key to unlocking the mysteries of chronic heart failure and skeletal muscle dysfunction.

REDUCTIONS IN EXERCISE CAPACITY in patients with chronic heart failure (CHF) were originally linked solely to central limitations associated with a malfunctioning cardiac pump. However, over the last 20 years, peripheral factors related to skeletal muscle and the vascular/skeletal muscle interface have been implicated in this phenomenon. Specifically, muscle atrophy, fiber-type alterations, red...

Neuro-psychopharmacogenetics and Neurological Antecedents of Posttraumatic Stress Disorder: Unlocking the Mysteries of Resilience and Vulnerability

BACKGROUND AND HYPOTHESIS Although the biological underpinnings of immediate and protracted trauma-related responses are extremely complex, 40 years of research on humans and other mammals have demonstrated that trauma (particularly trauma early in the life cycle) has long-term effects on neurochemical responses to stressful events. These effects include the magnitude of the catecholamine respo...